Bake at 425 degrees F for 9-15 minutes, until an instant read thermometer shows internal temperature is 145 degrees F. Thicker cuts will take longer, thinner cuts will cook faster. General cooking time is about 10 minutes per 1 inch of thickness. Fish will flake easily with a fork when done and will no longer look translucent, but using a thermometer is the only way to be sure the fish is cooked correctly..